Cytologic evidence of MM in the pleural or ascitic
fluid is found in 33-84% of cases.
A group of immunohistochemical markers is
important in the diagnosis of MM.
Initially, one has to differentiate if the tissue is
mesothelial in origin by checking for the presence
of markers such as calretinin, WT 1 antigen.
Secondly, one has to determine if the cells are
malignant by testing for the marker known as
epithelial membrane antigen (EMA, aka CA 15-3
and mucin-1)
Cytologic analysis is sufficient to make a diagnosis
with a high level of confidence in about 80% of the
cases, if done by an experienced pathologist.
Conclusion
14 years ago
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