There are 4 principal processes by which asbestos
affects the pleura
The fibers irritate the pleura, thereby inducing
scarring or a more malignant process
The fibers may pierce the mitotic spindle of cells,
thereby disrupting mitosis leading to
chromosomal damage
They also induce the generation of iron-related
reactive oxygen species (ROS) causing DNA
damage
Asbestos also induces phosphorylation of the
mitogen-activated protein (MAP) kinases which
increases the expression of early-response proto-
oncogenes
Conclusion
14 years ago
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